[Effect of infection on the immune system in burns in animal experiments]

After discussing a model of infection in mice and the possibility of active immunization against pyocyanic pseudomonas, the authors describe the effect of a lipid-protein-complex achieved from isolated burnt mouse skin on pseudomonas infection. First results showed that sublethal amounts of that complex at otherwise less pathogenic suspension of pseudomonas cause a lethality of 100 per cent. This effect can partially inhibited by application of antitoxic IgG. The lethal course was not primarily caused by the infection but by the above mentioned complex which significantly lowers the resistance against pyocyanic pseudomonas.