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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Clinical characteristics of hospitalized patients with hepatitis E virus infection in Poland: a multi-centre
Anna Parfieniuk-Kowerda1, Jerzy Jaroszewicz2, Piotr Grabarczyk3
1Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
Purpose:
The burden of hepatitis E virus (HEV) infections in Poland is highly underestimated and in contrast with high anti-HEV IgG seroprevalence in Polish population. This is the first publication addressing the issues of HEV infections in Poland as well as surveillance and reporting problems referring to this particular disease.
Patients And Methods:
In this retrospective study we analysed 61 HEV cases referred to and diagnosed in 10 leading centres in Poland.
Results:
Males constituted 70.5% of the study group, with equal distribution of cases below and over 50 years of age. Comorbidities were reported in 73.8% of this group. Of major concern was the high frequency of reported complications and clinical outcomes: 3 cases of acute liver failure (ALF) with 1 resulting in orthotopic liver transplantation (OLTx), 1 case of renal insufficiency, 3 cases of neuralgic amyotrophy, 8 cases of thromocytopaenia, and 4 cases of chronic hepatitis E.
Conclusions:
The HEV infections in Poland are considerably underestimated, which results both from the lack of awareness of general practitioners and limited access to HEV diagnostics, particularly in primary and secondary care medical facilities in Poland.
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