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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
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Basics of Neonatal Herpes Simplex Virus.
Jocquelin V Jones1, Megan Falke2
1Mednax Medical Group, Sunrise, FL, USA.
Neonatal Network : NN
|February 26, 2026
Summary
Neonatal herpes simplex virus (HSV) infection is preventable, yet causes significant infant harm. Early recognition and prevention strategies are key to reducing infant morbidity and mortality from this serious neonatal condition.
Area of Science:
- Neonatal infections
- Virology
- Public Health
Background:
- Neonatal herpes simplex virus (HSV) infection is a serious complication of maternal HSV.
- It is associated with high morbidity and mortality, including long-term neurologic impairment.
- Despite advances, it remains a significant concern in neonatal care.
Purpose of the Study:
- To review the epidemiology, transmission, clinical features, diagnosis, treatment, and prevention of neonatal HSV.
- To highlight the preventable nature of neonatal HSV infections.
- To emphasize the importance of clinical awareness and prevention strategies.
Main Methods:
- Literature review of epidemiology, transmission, clinical manifestations, diagnosis, treatment, and prevention.
- Analysis of current treatment advances and prevention strategies.
- Examination of challenges in identifying asymptomatic maternal infections.
Main Results:
- Neonatal HSV infection is a significant cause of infant morbidity and mortality.
- Most neonatal cases arise from mothers without a prior HSV diagnosis.
- Prevention includes suppressional therapy and C-section for active lesions.
Conclusions:
- Neonatal HSV infection is a preventable cause of infant morbidity and mortality.
- Healthcare provider awareness is crucial for early detection and treatment.
- Identifying asymptomatic maternal infections is a critical challenge for prevention.
