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Targeting metabolic vulnerabilities with advanced delivery systems

Wanlin Ye1, Xin Li1, Jocelyn Chandra1

  • 1Department of Pharmaceutical Science, Division of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R. China; Department of Biomedical Sciences, Division of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R. China.

Trends in Pharmacological Sciences
|February 26, 2026
PubMed

Insights

Precision oncology advances by targeting cancer cell metabolism. New metabolism-modulating drug delivery systems (MDDSs) offer targeted interventions, overcoming previous limitations in clinical translation.

Area of Science:

  • Oncology
  • Metabolic Engineering
  • Drug Delivery Systems

Background:

  • Metabolism modulation is a key strategy in precision oncology.
  • Targeting unique metabolic vulnerabilities of cancer cells in vivo remains a significant challenge.
  • Advanced delivery systems are enabling targeted metabolic interventions.

Purpose of the Study:

  • To evaluate the progress of metabolism-modulating drug delivery systems (MDDSs) in precision oncology.
  • To highlight a path forward for MDDSs in clinical translation.
  • To discuss translational barriers and propose solutions for developing metabolism-based therapeutics.

Main Methods:

  • Review of current strategies integrating tumor metabolism with advanced delivery systems.
  • Analysis of key translational barriers including metabolic heterogeneity, biological barriers, and off-target effects.
  • Exploration of emerging solutions like metabolic circuit mapping and AI-driven carrier design.

Main Results:

  • MDDSs show promise for targeted metabolic intervention in precision oncology.
  • Significant translational barriers hinder clinical application.
  • Emerging solutions offer potential to overcome these challenges.

Conclusions:

  • MDDSs represent a promising frontier in precision oncology.
  • Addressing translational barriers is crucial for clinical success.
  • Innovative approaches are needed to advance metabolism-based therapeutics.
Keywords:
drug delivery systemsimmunometabolic interactionsmetabolism modulationpharmaceutical preparationsprecision oncology

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