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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

51
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

80
Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
80
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

269
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
269
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

77
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Targeting metabolic vulnerabilities with advanced delivery systems.

Wanlin Ye1, Xin Li1, Jocelyn Chandra1

  • 1Department of Pharmaceutical Science, Division of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R. China; Department of Biomedical Sciences, Division of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R. China.

Trends in Pharmacological Sciences
|February 26, 2026
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Precision oncology advances by targeting cancer cell metabolism. New metabolism-modulating drug delivery systems (MDDSs) offer targeted interventions, overcoming previous limitations in clinical translation.

Keywords:
drug delivery systemsimmunometabolic interactionsmetabolism modulationpharmaceutical preparationsprecision oncology

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Area of Science:

  • Oncology
  • Metabolic Engineering
  • Drug Delivery Systems

Background:

  • Metabolism modulation is a key strategy in precision oncology.
  • Targeting unique metabolic vulnerabilities of cancer cells in vivo remains a significant challenge.
  • Advanced delivery systems are enabling targeted metabolic interventions.

Purpose of the Study:

  • To evaluate the progress of metabolism-modulating drug delivery systems (MDDSs) in precision oncology.
  • To highlight a path forward for MDDSs in clinical translation.
  • To discuss translational barriers and propose solutions for developing metabolism-based therapeutics.

Main Methods:

  • Review of current strategies integrating tumor metabolism with advanced delivery systems.
  • Analysis of key translational barriers including metabolic heterogeneity, biological barriers, and off-target effects.
  • Exploration of emerging solutions like metabolic circuit mapping and AI-driven carrier design.

Main Results:

  • MDDSs show promise for targeted metabolic intervention in precision oncology.
  • Significant translational barriers hinder clinical application.
  • Emerging solutions offer potential to overcome these challenges.

Conclusions:

  • MDDSs represent a promising frontier in precision oncology.
  • Addressing translational barriers is crucial for clinical success.
  • Innovative approaches are needed to advance metabolism-based therapeutics.