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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Related Experiment Video

Updated: Feb 28, 2026

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
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Testing of Pre-Operative Peripheral Nerve Blocks in Randomised Controlled Trials: A Scoping Review.

Aurelien-Xuan Rosendal Bahuet1, Rasmus Linnebjerg Knudsen1, Mathias Therkel Steensbæk1

  • 1Department of Anaesthesiology, Copenhagen University Hospital, Hillerød, Denmark.

Acta Anaesthesiologica Scandinavica
|February 26, 2026
PubMed
Summary
This summary is machine-generated.

Most randomized trials on peripheral nerve blocks (PNBs) report testing, but many fail to define success or report rates. Standardized reporting is crucial for comparing PNB studies and improving clinical practice.

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Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
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Area of Science:

  • Anesthesiology
  • Clinical Research Methodology
  • Regional Anesthesia

Background:

  • Peripheral nerve blocks (PNBs) are integral to anesthesia for limb surgeries.
  • Current assessment methods for PNB success lack standardization across studies.
  • This review evaluates contemporary practices in reporting PNB evaluation in research.

Purpose of the Study:

  • To conduct a scoping review of randomized controlled trials (RCTs) on peripheral nerve blocks.
  • To examine current research practices in reporting PNB evaluation.
  • To identify the extent of reporting on PNB testing methods and success criteria.

Main Methods:

  • Searched PubMed for RCTs on pre-operative PNBs in adult limb surgery (2014-2025).
  • Two independent reviewers screened trials and extracted data on block testing, methods, success definitions, and rates.
  • Analyzed reporting proportions for key evaluation outcomes.

Main Results:

  • 284 RCTs were included; 76% reported block testing, and 74% described test methods.
  • Sensory assessments were used in 95% of trials that reported testing, motor assessments in 73%.
  • Success criteria were defined in 58% of trials, and success rates reported in the same proportion, with a median of 98%.

Conclusions:

  • Most RCTs report PNB testing, but a significant proportion omit success definitions and rates.
  • Inconsistent reporting of PNB methodology hinders trial comparability and clinical translation.
  • Standardized reporting guidelines for regional anesthesia assessment are needed to address this research gap.