Diagnostic performance of thromboelastography and systemic inflammatory indicators in chronic glomerulonephritis: a...

Area of Science:

• Nephrology and Hematology
• Diagnostic Biomarkers
• Inflammation and Coagulation

Background:

• Chronic glomerulonephritis (CGN) diagnosis relies on invasive methods.
• There is a need for non-invasive, effective auxiliary diagnostic tools for CGN.
• Thromboelastography (TEG) and systemic inflammation indicators have potential as diagnostic aids.

Purpose of the Study:

• To evaluate TEG parameters and systemic inflammatory indicators as auxiliary diagnostic tools for CGN.
• To assess the clinical applicability and effectiveness of these combined markers.
• To establish reference data for future biomarker studies in CGN.

Main Methods:

• A case-control study involving 419 CGN patients and 419 healthy controls.
• TEG was used to measure coagulation function; automated analyzers measured blood indices.
• Systemic inflammation index was calculated, and associations were analyzed.

Main Results:

• CGN patients showed significantly elevated inflammatory markers (SIRI, SII, NLR, WBC) and altered coagulation parameters (increased Angle, MA; decreased K, LY30) compared to controls.
• Age, Angle, MA, LY30, WBC, and SIRI were identified as independent risk factors for CGN.
• Combining age, TEG, and inflammatory indicators achieved an AUC of 0.782 for CGN diagnosis.

Conclusions:

• TEG parameters and inflammatory indicators are significantly associated with CGN.
• These markers demonstrate potential as clinically applicable auxiliary diagnostic tools for CGN.
• The reported data and thresholds can guide future research on CGN biomarkers.