Related Experiment Video
Updated: Feb 28, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
panTB-HM: a multi-arm clinical trial of a pan-TB regimen targeting both host and microbe
D Mudzengi1, S Mashatole2, Q Xiang2,3
1Aurum Institute, Johannesburg, South Africa. dmudzengi@auruminstitute.org.
Background:
Newer oxazolidinones will be required to advance regimens in pan-TB indications. The addition of host-directed agents may help promote the recovery of lung function during TB treatment and prevent post-TB lung disease.
Methods:
The panTB-HM trial assesses the capacity of three novel regimens containing the oxazolidinone sutezolid and the antioxidant N-acetylcysteine (NAC) to meet the target criteria proposed by WHO for pan-TB indications (including use without rifamycin susceptibility testing and of 4 months or less duration) in a phase 2C trial.
Discussion:
This trial is ground-breaking in its objectives and design for a 4-month pan-TB indication (in a non-inferiority comparison to standard treatment) and its evaluation of lung function recovery (in a superiority comparison).
Trial Registration:
ClinicalTrials.gov NCT05686356. Registered on 13 Jan 2023.
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