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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Association of Cardiovascular-Kidney-Syndrome and Brain Macrostructure and Microstructure Injury: A Prospective
Guanyu Niu1,2, Xueli Cai3,4, Yingying Yang1,2
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Diabetes, Obesity & Metabolism
|February 26, 2026
Summary
Cardiovascular-kidney-metabolic (CKM) syndrome severity is linked to brain structure changes. Early CKM syndrome detection may help preserve brain health and delay cognitive decline.
Area of Science:
- Neurology
- Cardiology
- Metabolic Health
Background:
- Cardiovascular-kidney-metabolic (CKM) syndrome is a growing public health concern.
- Understanding its impact on brain health is crucial for preventative strategies.
Purpose of the Study:
- To investigate the association between CKM syndrome stages and brain macrostructure and microstructure.
- To explore both cross-sectional and longitudinal relationships.
Main Methods:
- Prospective community-based cohort study of 3067 adults aged 50-75 years.
- CKM syndrome staging (0-4) based on American Heart Association criteria.
- Brain MRI including volumetric assessment, white matter hyperintensity volume (WMHV), and diffusion tensor imaging (DTI) over three waves.
Main Results:
- Advanced CKM stages (3-4) correlated with reduced brain volumes and increased WMHV cross-sectionally.
- Higher baseline CKM stages (2-3) predicted accelerated brain volume decline and WMHV progression longitudinally.
- DTI revealed progressive white matter microstructural deterioration, from focal to widespread integrity loss, in higher CKM stages.
Conclusions:
- CKM syndrome severity is associated with significant brain macrostructural and microstructural abnormalities.
- Progressive white matter deterioration is an early indicator, with macrostructural changes also evident.
- Early CKM syndrome identification and management are vital for mitigating brain health decline.
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