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Related Concept Videos

Phase Contrast and Differential Interference Contrast Microscopy01:26

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Updated: Feb 28, 2026

Human Egg Maturity Assessment and Its Clinical Application
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Clinical Outcomes of ICSI Using Advanced Quantitative Phase Microscopy.

Roni Rahav-Koren1,2, Luba Nemerovsky1,2, Yehudith Ghetler1,2

  • 1In Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428163, Israel.

Bioengineering (Basel, Switzerland)
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Quantitative phase microscopy (QPM) significantly improves pregnancy and delivery rates for intracytoplasmic sperm injection (ICSI). This advanced sperm selection method offers a safe, non-invasive approach for couples facing male infertility challenges.

Keywords:
intracytoplasmic sperm injectionquantitative phase microscopy (QPM)sperm selection

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Area of Science:

  • Reproductive Medicine
  • Microscopy Techniques
  • Infertility Diagnostics

Background:

  • Intracytoplasmic sperm injection (ICSI) is a key assisted reproductive technology.
  • Sperm selection is crucial for ICSI success.
  • Current sperm selection methods have limitations in assessing sperm morphology.

Purpose of the Study:

  • To evaluate the clinical outcomes of using quantitative phase microscopy (QPM) for sperm selection in ICSI.
  • To compare QPM-assisted ICSI with conventional ICSI and intracytoplasmic morphologically selected sperm injection (IMSI).

Main Methods:

  • Prospective comparison of three groups: QPM-assisted ICSI, conventional ICSI (same patient), and historical conventional ICSI.
  • Comparison between QPM-assisted ICSI and IMSI cycles.
  • Inclusion of 1243 total cycles.

Main Results:

  • Pregnancy and delivery rates were significantly higher in the QPM group compared to standard ICSI (56.2% vs. 18.1% and 50% vs. 9%, respectively).
  • Pregnancy and delivery rates were also significantly higher in the QPM group compared to the IMSI group (56.2% vs. 16.6% and 50% vs. 16.6%, respectively).
  • No pregnancy complications were observed in the QPM group.

Conclusions:

  • Quantitative phase microscopy (QPM) is a safe and non-invasive sperm selection technique for ICSI.
  • QPM has the potential to improve clinical pregnancy and delivery rates.
  • QPM offers a promising advancement for couples experiencing male infertility.