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Clinical Outcomes of ICSI Using Advanced Quantitative Phase Microscopy
Roni Rahav-Koren1,2, Luba Nemerovsky1,2, Yehudith Ghetler1,2
1In Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428163, Israel.
Bioengineering (Basel, Switzerland)
|February 27, 2026
Summary
Quantitative phase microscopy (QPM) significantly improves pregnancy and delivery rates for intracytoplasmic sperm injection (ICSI). This advanced sperm selection method offers a safe, non-invasive approach for couples facing male infertility challenges.
Area of Science:
- Reproductive Medicine
- Microscopy Techniques
- Infertility Diagnostics
Background:
- Intracytoplasmic sperm injection (ICSI) is a key assisted reproductive technology.
- Sperm selection is crucial for ICSI success.
- Current sperm selection methods have limitations in assessing sperm morphology.
Purpose of the Study:
- To evaluate the clinical outcomes of using quantitative phase microscopy (QPM) for sperm selection in ICSI.
- To compare QPM-assisted ICSI with conventional ICSI and intracytoplasmic morphologically selected sperm injection (IMSI).
Main Methods:
- Prospective comparison of three groups: QPM-assisted ICSI, conventional ICSI (same patient), and historical conventional ICSI.
- Comparison between QPM-assisted ICSI and IMSI cycles.
- Inclusion of 1243 total cycles.
Main Results:
- Pregnancy and delivery rates were significantly higher in the QPM group compared to standard ICSI (56.2% vs. 18.1% and 50% vs. 9%, respectively).
- Pregnancy and delivery rates were also significantly higher in the QPM group compared to the IMSI group (56.2% vs. 16.6% and 50% vs. 16.6%, respectively).
- No pregnancy complications were observed in the QPM group.
Conclusions:
- Quantitative phase microscopy (QPM) is a safe and non-invasive sperm selection technique for ICSI.
- QPM has the potential to improve clinical pregnancy and delivery rates.
- QPM offers a promising advancement for couples experiencing male infertility.
