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A Novel, Low-Cost, 3D-Printed Motorized Injector for Retinal Sheet Transplantation.

Jerald Lim1,2,3, Francis Ung2,4, Samir Malhotra2,4,5

  • 1School of Medicine, University of California Irvine, Irvine, CA 92697, USA.

Bioengineering (Basel, Switzerland)
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

A new 3D-printed motorized injector improves retinal sheet delivery accuracy and stability. This novel device reduces tissue damage and misplacements, enhancing subretinal transplantation for vision restoration in retinal degeneration.

Keywords:
3D printinstrumentorganoidretinatransplant

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Area of Science:

  • Biomedical Engineering
  • Ophthalmology
  • Regenerative Medicine

Background:

  • Retinal transplantation shows potential for vision restoration in advanced retinal degeneration.
  • Manual delivery of retinal sheets faces challenges including imprecise placement and tissue damage due to instrument instability.

Purpose of the Study:

  • To introduce a novel, 3D-printed, motorized retinal sheet injector.
  • To enhance placement accuracy and minimize tissue injury during subretinal delivery.

Main Methods:

  • Development of a 3D-printed, motorized retinal sheet injector controlled by an Arduino-based foot pedal.
  • Comparative analysis of the motorized injector against manual methods using frame-by-frame motion analysis and in vitro gelatin trials.

Main Results:

  • The motorized system demonstrated a threefold reduction in tip variance compared to manual methods.
  • In vitro trials showed significantly higher placement accuracy with the motorized injector, avoiding occasional complete misplacements seen with manual delivery.

Conclusions:

  • The novel motorized retinal sheet injector significantly improves stability and accuracy in subretinal delivery.
  • This technology has the potential to reduce complications associated with subretinal transplantation and advance treatments for retinal diseases.