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Related Experiment Video

Updated: Feb 28, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

Novel Experimental Setup for Ascending Thoracic Aortic Aneurysm Inflation Testing.

Hugo Mesquita Vasconcelos¹, Daniela Azevedo¹, Rodrigo Valente²

¹Institute of Science and Innovation in Mechanical Engineering and Industrial Engineering (INEGI), Campus da FEUP, R. Dr. Roberto Frias 400, 4200-465 Porto, Portugal.

Bioengineering (Basel, Switzerland)

|February 27, 2026

Summary

This summary is machine-generated.

A new experimental setup allows for ex vivo testing of aortic aneurysm (ATAA) tissue. This method uses a pneumatic system and 3D digital image correlation to measure deformation, aiding in better rupture prediction.

Keywords:

aortic aneurysm mechanics ascending thoracic aortic aneurysm full-field displacement analysis inflation testing

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Last Updated: Feb 28, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

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Published on: October 6, 2022

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

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Published on: June 29, 2014

A New Murine Model of Endovascular Aortic Aneurysm Repair

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

Area of Science:

Biomedical Engineering
Materials Science
Cardiovascular Research

Background:

Degraded aortic wall mechanics contribute to aortic aneurysms and life-threatening ruptures.
Current diagnostic methods based on maximum aortic diameter lack predictive accuracy for rupture events.
There is a critical need for patient-specific prediction methods for aortic aneurysm rupture.

Purpose of the Study:

To design and validate a hospital-compatible experimental apparatus for ex vivo inflation testing of Ascending Thoracic Aortic Aneurysm (ATAA) specimens.
To utilize 360° full-field three-dimensional digital image correlation (3D-DIC) for precise measurement of surface displacement.
To establish a practical framework for acquiring deformation data from intact aortic tissue for improved rupture prediction models.

Main Methods:

Developed a quasi-static ex vivo inflation testing system using a balloon-driven pneumatic setup, avoiding liquid pressurization constraints in a hospital setting.
Employed synchronized stereo imaging to capture surface displacement fields under pressures ranging from 80 to 120 mmHg.
Validated the apparatus using a CT-derived ATAA silicone phantom and demonstrated biological feasibility with a porcine aorta specimen.

Main Results:

The experimental apparatus demonstrated mechanical reliability and repeatability, with full-field displacement measurements closely matching finite element simulations.
The system successfully acquired inflation-induced deformation data from intact aortic specimens.
Speckle application and 3D-DIC tracking were feasible on biological tissue, paving the way for human ATAA studies.

Conclusions:

The developed experimental setup provides a practical and hospital-compatible method for ex vivo inflation testing of ATAA specimens.
This framework enables the acquisition of crucial deformation data for calibrating computational models.
The study contributes to developing more accurate patient-based rupture prediction methods for aortic aneurysms.