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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
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Current Research Progress on ABHD5 in Cancers.

Huazhong Cai1,2, Hao Chen1,2, Jiexing Ye3

  • 1Department of Emergency, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China.

Cancers
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Alpha/beta-hydrolase domain-containing protein 5 (ABHD5) has a dual role in cancer, acting as a tumor suppressor in some cancers and a promoter in others. Its complex functions highlight its potential as a nuanced therapeutic target.

Keywords:
ABHD5cancerlipid metabolismpathway

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Area of Science:

  • Oncology
  • Lipid Metabolism
  • Molecular Biology

Background:

  • Lipid metabolism is crucial for cancer development and treatment resistance.
  • Chanarin-Dorfman syndrome (CDS) highlights the role of alpha/beta-hydrolase domain-containing protein 5 (ABHD5) in lipid droplet mobilization.
  • ABHD5's role in cancer is context-dependent, acting as a tumor suppressor in some and a promoter in others.

Purpose of the Study:

  • To review the diverse and contradictory roles of ABHD5 in various cancers.
  • To map the context-dependent functions and molecular mechanisms of ABHD5 in cancer.
  • To explore ABHD5's potential as a diagnostic marker and therapeutic target.

Main Methods:

  • Review of experimental and clinical evidence.
  • Analysis of ABHD5's interaction with signaling pathways (AMPK/mTOR, AKT, NF-κB).
  • Examination of ABHD5's influence on cancer hallmarks (proliferation, invasion, apoptosis, immune evasion, drug response).

Main Results:

  • ABHD5 restrains tumor growth in lung, liver, and renal cell carcinoma.
  • ABHD5 promotes malignant progression in endometrial cancer.
  • ABHD5 has context-dependent roles in colorectal and prostate cancers.
  • ABHD5 influences cancer cell fate and behavior through key signaling pathways.

Conclusions:

  • ABHD5 exhibits context-specific functions in cancer, necessitating nuanced therapeutic strategies.
  • ABHD5's complex roles warrant further investigation as a potential diagnostic and therapeutic target.
  • Understanding ABHD5's molecular circuits is key to developing targeted anticancer interventions.