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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Stereotactic Radiosurgery for Gynecologic Cancer
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Two-Week Interval Hypofractionated Stereotactic Radiosurgery for Benign Intracranial Tumors: Volumetric Kinetics and

Seung Woo Hong1, Junhyung Kim2, Jinu Rim2

  • 1Department of Neurosurgery, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.

Cancers
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Hypofractionated stereotactic radiosurgery (hfSRS) at two-week intervals offers excellent tumor control for benign brain tumors. Fraction timing influences early tumor response without impacting long-term outcomes.

Keywords:
acoustic neuromabenign neoplasmpituitary adenomaradiobiologyradiosurgery

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Hypofractionated stereotactic radiosurgery (hfSRS) is used for complex benign intracranial tumors.
  • Optimal inter-fraction intervals for hfSRS are not well-defined, especially for slow-growing tumors.
  • This study investigates the impact of fixed two-week intervals in hfSRS.

Purpose of the Study:

  • To evaluate clinical outcomes of Gamma Knife hfSRS with fixed two-week intervals.
  • To analyze longitudinal volumetric response patterns in benign intracranial tumors treated with hfSRS.
  • To assess the biological relevance of fraction timing in hfSRS.

Main Methods:

  • Retrospective analysis of 126 patients with benign intracranial tumors (meningioma, PitNET, vestibular schwannoma, craniopharyngioma).
  • Treatment delivered in 2-5 fractions at fixed two-week intervals using Gamma Knife radiosurgery.
  • Propensity score matching used to compare hfSRS with single-fraction SRS for PitNET and vestibular schwannoma.

Main Results:

  • Overall tumor control rate was 98.4%.
  • hfSRS showed earlier and greater volumetric reduction in PitNET compared to single-fraction SRS.
  • Vestibular schwannoma patients treated with hfSRS experienced transient enlargement but maintained long-term control and hearing function.

Conclusions:

  • Fixed two-week intervals for hfSRS achieve excellent tumor control and acceptable toxicity in select benign intracranial tumors.
  • The findings support the clinical feasibility of a two-week inter-fraction interval.
  • Fraction timing appears biologically relevant, influencing early volumetric response without compromising long-term results.