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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Glioblastoma and Melatonin's Effects: A Narrative Review
Gaia Favero1,2, Francesca Sulas1, Mauro Labanca1,2,3
1Department of Clinical and Experimental Sciences, Università degli Studi di Brescia, 25123 Brescia, Italy.
Cancers
|February 27, 2026
Summary
Melatonin (MLT) may offer a novel therapeutic strategy for glioblastoma (GB), acting as a "smart killer" against cancer cells. Further research is needed to confirm MLT
Area of Science:
- Neuro-oncology
- Cancer biology
- Pharmacology
Background:
- Glioblastoma (GB) is a highly aggressive brain tumor with poor patient survival.
- Current treatments for GB have limited efficacy and significant side effects.
- Natural molecules are being explored for their chemotherapeutic potential.
Purpose of the Study:
- To review the potential of melatonin (MLT) as an adjuvant therapy for glioblastoma.
- To summarize MLT's role in modulating key intracellular pathways in GB.
- To highlight MLT's potential as a "smart killer" against cancer cells.
Main Methods:
- Literature review of recent findings on MLT and glioblastoma.
- Analysis of MLT's effects on intracellular pathways in GB.
- Evaluation of MLT's potential as a complementary treatment.
Main Results:
- Melatonin (MLT) shows potential in targeting cancer cells while sparing normal cells.
- MLT may modulate key intracellular pathways relevant to GB progression.
- MLT's "smart killer" behavior requires further investigation.
Conclusions:
- Melatonin (MLT) presents a promising complementary adjuvant therapy for glioblastoma.
- Clinical validation through randomized controlled trials is necessary.
- Multicenter studies are required to establish MLT's efficacy and optimal use in GB patients.
