Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling Relationships among Pain and Function in Individuals with Knee Osteoarthritis in the A2CPS Cohort.

The Clinical journal of pain·2026
Same author

The hijacked insula: A stratified model of affective touch modulation in chronic pain.

Journal of neuropsychology·2026
Same author

Training alpha to treat pain: dissociable pathways to analgesia.

Pain·2026
Same author

Intensity-dependent topographical expansion of sensory representations.

bioRxiv : the preprint server for biology·2026
Same author

Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.

bioRxiv : the preprint server for biology·2026
Same author

A predictive corticospinal model for pain perception.

Cell reports. Medicine·2026

Related Experiment Video

Updated: Jul 12, 2026

Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

265.8K

Transcranial Alternating Current Stimulation for Pain: Mixed Evidence and the Path to Precision Neuromodulation.

Yaser Fathi1, Amin Dehghani2, David M Gantz2

  • 1Institute of Neuroscience, Université Catholique de Louvain, 1200 Brussels, Belgium.

Brain Sciences
|February 27, 2026
PubMed
Summary

Transcranial alternating current stimulation (tACS) shows mixed results for pain relief. Future research needs standardized methods and personalized approaches to establish tACS as a reliable pain intervention.

Keywords:
alpha powerbrain imagingchronic painelectrophysiological recordingsexperimental painneural oscillationspain perceptiontACS

More Related Videos

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

12.0K
Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain
06:13

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain

Published on: March 1, 2024

1.9K

Related Experiment Videos

Last Updated: Jul 12, 2026

Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

265.8K
Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

12.0K
Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain
06:13

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain

Published on: March 1, 2024

1.9K

Area of Science:

  • Neuroscience
  • Pain Research
  • Neuromodulation

Background:

  • Neural oscillations are crucial for sensory, affective, and cognitive processing in pain perception.
  • Transcranial alternating current stimulation (tACS) is a tool to study and modulate brain oscillations related to pain.

Purpose of the Study:

  • To review the effects of tACS on pain perception and associated neural oscillations.
  • To identify methodological variability and mechanistic uncertainties contributing to inconsistent findings.

Main Methods:

  • Systematic review of 14 studies comparing tACS to sham interventions in healthy and chronic pain populations.
  • Analysis of targeted oscillatory features, primarily somatosensory alpha.

Main Results:

  • Eight out of 14 studies reported positive findings, including pain reduction or improved neural connectivity.
  • Significant heterogeneity in results was observed, with several studies showing no meaningful effects.
  • Variability attributed to differences in stimulation parameters, individual neurophysiology, and study design.

Conclusions:

  • Current evidence on tACS for pain is inconsistent due to methodological variability.
  • Future research requires pre-registered, adequately powered studies with neuroimaging to validate findings.
  • Personalized, state-dependent, closed-loop tACS approaches hold promise for reliable pain intervention.