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MAC/MAB-RCS: An Integrative Regulatory Control Framework for Risk Stratification and Personalized Intervention in
Anna Makarewicz1, Remigiusz Recław2,3, Anna Grzywacz2,3
1Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.
The MAC/MAB-RCS model offers a new framework for addiction psychiatry, integrating biomarkers, brain networks, and psychological factors. This approach aids in early risk identification and personalized interventions for addiction disorders.
Area of Science:
- Psychiatry
- Neuroscience
- Behavioral Science
Background:
- Addiction disorders present significant challenges with high relapse rates.
- Current models lack tools for early risk identification and dynamic clinical decision-making.
Purpose of the Study:
- Introduce the MAC/MAB-RCS model as an integrated framework.
- Facilitate risk stratification and personalized interventions in addiction psychiatry.
Main Methods:
- Integrate genetic, epigenetic, and stress-axis biomarkers.
- Incorporate functional brain network organization.
- Synthesize psychological and psychiatric dimensions of addictive behaviors.
Main Results:
- The Regulatory Control State (RCS) is central, representing dynamic regulatory capacity.
- Disrupted RCS is a transdiagnostic mechanism for craving, compulsive behavior, and relapse.
- The model captures dynamic regulatory processes underlying addiction vulnerability.
Conclusions:
- The MAC/MAB-RCS model supports precision psychiatry principles.
- It provides a clinically oriented translational framework.
- Potential applications exist across clinical settings, bridging research and practice.
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