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Published on: January 13, 2017
New Pyridinone Alkaloid and Polyketide from the Cordyceps-Colonizing Fungus Pseudogymnoascus roseus
Jie Lin1, Yutong Guo2, Jing Wang2
1Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing 210013, China.
Abstract:
One new pyridinone alkaloid pseudogymnone A (1) and one new tricyclic polyketide penijanthinone C (2), together with six known compounds, harzianic acid (3), 3-methyl-2-(2-nonenyl)-4(1H)-quinolinone (4), emodic acid (5), alaternin (6), violaceol-I (7), and violaceol-II (8), were obtained from the Cordyceps-colonizing fungus Pseudogymnoascus roseus. The structures and absolute configurations of the isolated compounds were elucidated through a combination of NMR and MS spectroscopic analyses, ECD calculations, and X-ray crystallography. Compound 3 exhibited obvious cytotoxicity against A549 (IC50 = 4.2 µM) and MGC (IC50 = 3.8 µM) cell lines. Integrated network pharmacology and molecular docking analyses indicated that compound 3 exerts potential anti-gastric-cancer effects by modulating multiple cancer-related signaling pathways, with EGFR identified as a potential target of compound 3.
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