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Updated: Feb 28, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
Hepatocyte-Derived Apoptotic Bodies as Pathological Intercellular Messengers in the Liver
Moses New-Aaron1,2, Lukman A Adepoju3, Anup Singh Pathania3
1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Hepatocyte apoptotic bodies (ApopBDs) are crucial for liver intercellular communication, influencing inflammation and regeneration. Understanding ApopBDs offers new therapeutic strategies for liver diseases.
Area of Science:
- Hepatology
- Cell Biology
- Immunology
Background:
- Hepatocyte apoptotic bodies (ApopBDs) were initially viewed as cellular debris.
- Emerging evidence highlights ApopBDs as key mediators of intercellular communication in the liver.
Purpose of the Study:
- To review the biogenesis, characterization, and roles of ApopBDs in liver diseases.
- To emphasize the role of ApopBDs in intercellular communication with liver-resident cells.
Main Methods:
- Literature review focusing on hepatocyte apoptosis and ApopBDs.
- Analysis of ApopBDs' involvement in liver injury mechanisms and intercellular crosstalk.
- Discussion of diagnostic and therapeutic potentials of ApopBDs.
Main Results:
- ApopBDs influence inflammation, regeneration, and fibrosis through intercellular communication.
- Liver injury involves complex crosstalk between ApopBDs and surviving liver cells.
- Proinflammatory and profibrotic pathways (e.g., TLR9/NLRP3, JAK-STAT3) are implicated in liver injury progression.
Conclusions:
- ApopBDs play a significant role in the pathogenesis of various liver diseases.
- Hepatocyte-specific signatures on ApopBDs suggest potential as diagnostic biomarkers.
- Further understanding of ApopBDs may lead to novel therapeutic interventions for liver damage.
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