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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Renoprotection by 5-Methoxytryptophan in Kidney Disease

Jonah P Gutierrez1, Tram N Diep1, Shaona Niu1

  • 1Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Biomolecules
|February 27, 2026
PubMed
Summary

5-methoxytryptophan (5-MTP), a tryptophan metabolite, shows protective effects against kidney injury. Lower serum 5-MTP levels in chronic kidney disease (CKD) suggest its potential as a biomarker and therapeutic agent.

Keywords:
5-methoxytryptophan (5-MTP)fibrosisinflammationkidneymitophagyoxidative damage

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