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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

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Related Experiment Video

Updated: May 11, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Modulation and Reprogramming of Adipose Tissue Macrophages in Obesity.

Yan Liu¹, Xiaoying Huang¹, Linfeng Sang¹

¹Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, China.

|February 27, 2026

Summary

Obesity-induced chronic inflammation involves reprogramming of adipose tissue macrophages (ATMs) and their metabolic pathways. This review details ATM metabolic changes and regulatory mechanisms in obesity-related inflammation and dysfunction.

Keywords:

adipose tissue macrophages metabolic reprogramming obesity

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Last Updated: May 11, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Area of Science:

Immunology
Metabolism
Obesity Research

Background:

Obesity is linked to chronic inflammation, driving metabolic dysfunction.
Adipose tissue macrophages (ATMs) are key immune cells in adipose tissue, mediating inflammation in obesity.
ATM heterogeneity and function are central to metabolic dysregulation.

Purpose of the Study:

To review the metabolic reprogramming of ATMs in obesity.
To highlight the role of ATMs in chronic metabolic inflammation.
To discuss mechanisms regulating ATM remodeling in obesity.

Main Methods:

Literature review focusing on metabolic pathways in ATMs.
Analysis of transcriptional and epigenetic regulation of ATMs.
Synthesis of current research on ATM function in obesity.

Main Results:

ATMs undergo significant metabolic pathway reprogramming in obesity.
Altered glucose and lipid homeostasis in ATMs contribute to inflammation.
Transcriptional and epigenetic factors drive ATM remodeling.

Conclusions:

ATM metabolic reprogramming is a critical factor in obesity-induced inflammation.
Understanding these mechanisms can inform therapeutic strategies for metabolic diseases.
Targeting ATM metabolism offers potential for managing obesity-related complications.