Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left ventricular deformation in chronic schizophrenia-a detailed analysis from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study.

Quantitative imaging in medicine and surgery·2026
Same author

Right Atrial Mechanics in Healthy Mid-Term Pregnancy-An Analysis from a Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Preg Study.

Biomedicines·2026
Same author

Left Atrial Volumes and Strains in Healthy Mid-Term Pregnancy-A Detailed Investigation from a Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Preg Study.

Biomedicines·2026
Same author

Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium.

Basic research in cardiology·2026
Same author

Evaluation of <i>Echinacea</i> Leaf Extract and Allantoin Based Topical Formulations in an Imiquimod-Induced Psoriasis-like Model.

Medical sciences (Basel, Switzerland)·2026
Same author

Trimethylamine N-oxide in exercise physiology: a gut microbiota-derived signal linking metabolic stress, redox balance and cardiometabolic health.

European journal of applied physiology·2026

Related Experiment Video

Updated: Feb 28, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
06:26

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

8.4K

Temporal Exercise Conditioning Confers Dual-Phase Cardioprotection Against Isoproterenol-Induced Injury in a Rat

Krisztina Kupai1,2, Zsolt Murlasits3, Hsu Lin Kang1

  • 1Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, 6703 Szeged, Hungary.

Antioxidants (Basel, Switzerland)
|February 27, 2026
PubMed
Summary

Moderate exercise training offers cardioprotection against myocardial infarction (MI) by improving cardiac function and reducing oxidative stress. Timed exercise, particularly post-MI, significantly mitigates heart damage and enhances recovery.

Keywords:
cardioprotectionmoderate exercisepostconditioningpreconditioning

More Related Videos

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.7K
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

3.1K

Related Experiment Videos

Last Updated: Feb 28, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
06:26

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

8.4K
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.7K
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

3.1K

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Biochemistry

Background:

  • Cardiovascular diseases, including myocardial infarction (MI), pose significant health challenges.
  • Exercise training is recognized for its potential to mitigate adverse cardiovascular events.
  • Isoproterenol (ISO)-induced heart damage in rats serves as a model for studying MI effects.

Purpose of the Study:

  • To investigate the cardioprotective effects of moderate exercise before and after isoproterenol (ISO)-induced myocardial infarction in Wistar rats.
  • To evaluate the impact of exercise timing on cardiac function and oxidative stress markers.

Main Methods:

  • Wistar rats were divided into five groups: control, ISO-induced MI, exercise before MI, exercise after MI, and exercise both before and after MI.
  • Cardiac function was assessed using echocardiography (measuring stroke volume, ejection fraction, and Tei index).
  • Oxidative stress markers, including Heme Oxygenase-1 (HO-1) and Myeloperoxidase (MPO), were quantified via biochemical assays and ELISA.

Main Results:

  • Exercise initiated post-MI and exercise both pre- and post-MI significantly reduced infarct size and improved cardiac function.
  • HO-1 levels and activity were restored in exercise groups compared to the ISO-only group.
  • Swim training reduced MPO activity, indicating decreased inflammation.

Conclusions:

  • Moderate exercise training, especially when timed appropriately around myocardial infarction, confers significant cardioprotection.
  • Exercise mitigates ISO-induced cardiac dysfunction and oxidative stress.
  • Timed exercise interventions can be a valuable strategy in managing heart damage post-MI.