Biosacetalin (1,1-Diethoxyethane) Improves Healthy Lifespan in C. elegans and Rats.

Area of Science:

• Biochemistry
• Gerontology
• Mitochondrial Biology

Background:

• Reactive oxygen species (ROS) and signaling pathways like SIRT1, AMPK, and mTOR are crucial in aging.
• Mitochondrial complex I interactions and subsequent signaling pathway activation are key targets for longevity research.

Purpose of the Study:

• To investigate the effects of 1,1-diethoxyethane (1,1-DEE) on aging and longevity in model organisms.
• To explore 1,1-DEE's potential as a small-molecule modulator of mitochondrial function and redox signaling.

Main Methods:

• Assessed senescence in EA.hy926 endothelial cells.
• Administered 1,1-DEE to *Caenorhabditis elegans* (C. elegans) and rat models.
• Evaluated lifespan, survival rate, mortality risk, restricted mean survival time (RMST), and median lifespan in rats.
• Tested learning and memory in rats using the Morris water maze.

Main Results:

• 1,1-DEE decreased endothelial cell senescence.
• In *C. elegans*, 1,1-DEE induced hormesis and extended lifespan, unlike its isoform 1,2-DEE.
• In rats, 1,1-DEE significantly improved survival metrics and accelerated body weight reduction.
• 1,1-DEE enhanced learning and memory in rats.

Conclusions:

• 1,1-DEE acts as a novel small-molecule modulator of mitochondrial function and redox signaling.
• 1,1-DEE demonstrates significant potential for promoting anti-aging and longevity.