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Inducing Ferroptosis: Sensitization Strategy for Radiotherapy and Its Application
Xun Chen1, Shangwu Chen2, Dongsheng Yu1
1Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Antioxidants (Basel, Switzerland)
|February 27, 2026
Summary
Ferroptosis, a cell death pathway, is induced by radiation therapy. Combining ferroptosis inducers with radiotherapy synergistically enhances cancer cell death, offering a promising radiosensitization strategy.
Area of Science:
- Biomedical science
- Cancer research
- Cell death mechanisms
Background:
- Ferroptosis is a regulated cell death pathway driven by iron-dependent reactive oxygen species (ROS) and lipid peroxidation.
- Ferroptosis plays a significant role in the response to cancer radiotherapy.
- Radiotherapy induces tumor cell death via DNA damage and ROS production, contributing to oxidative stress.
Purpose of the Study:
- To review the characteristics and regulation of ferroptosis.
- To analyze the mechanisms by which radiotherapy induces ferroptosis.
- To discuss strategies for inducing ferroptosis to enhance radiosensitization.
Main Methods:
- Literature review of ferroptosis and radiotherapy.
- Analysis of molecular mechanisms linking ionizing radiation and ferroptosis.
- Synthesis of current strategies for ferroptosis induction in cancer therapy.
Main Results:
- Ionizing radiation can directly induce ferroptosis in tumor cells.
- Combining radiotherapy with ferroptosis inducers shows synergistic effects.
- Ferroptosis induction is a viable strategy to improve tumor cell sensitivity to radiotherapy.
Conclusions:
- Ferroptosis is a key mediator in radiotherapy response.
- Targeting ferroptosis offers a promising approach for cancer radiosensitization.
- Further research into ferroptosis induction strategies is warranted to optimize cancer treatment.
