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Updated: Feb 28, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Fetal Hemoglobin Modulation in Sickle Cell Disease: βs Haplotypes, Key Polymorphisms Identified by GWAS, and Advances

Yusselfy Márquez-Benitez1,2, Valeria Isabela Osorio-Garzón2, Jaime Eduardo Bernal-Villegas3

  • 1Doctoral Program in Biosciences, Faculty of Engineering, Universidad de La Sabana, Campus del Puente del Común, Km 7 Autopista Norte de Bogotá, Chía 250001, Cundinamarca, Colombia.

Genes
|February 27, 2026
PubMed
Summary

Fetal hemoglobin (HbF) is key to managing sickle cell disease (SCD). Genetic factors and advanced gene editing, like prime editing, offer new ways to boost HbF levels for better SCD treatment.

Keywords:
fetal hemoglobingamma-globinsgene editinggenome-wide association studyhaplotypespolymorphismssickle cell disease

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