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Updated: Feb 28, 2026
09:58
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
3.2K
DDX10 RNA Helicase: Structure, Function, and Oncogenic Roles Across Solid and Hematologic Tumors.
Giorgia Isinelli1, Genny Scacci1, Arianna Capocchia1
1Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
Genes
|February 27, 2026
Summary
DEAD-box RNA helicase DDX10 is crucial in cancer, regulating RNA metabolism and gene expression. Its dysregulation drives oncogenesis, making DDX10 a potential biomarker and therapeutic target for various malignancies.
Area of Science:
- Molecular Biology
- Cancer Biology
- RNA Metabolism
Background:
- DEAD-box (DDX) RNA helicases are vital for RNA metabolism and gene expression.
- DDX10's specific roles and involvement in human diseases are not well understood.
- Emerging evidence links DDX10 to various cancers.
Purpose of the Study:
- To provide a comprehensive review of DDX10's structure, function, and roles in cancer.
- To explore DDX10's involvement in pre-rRNA processing, ribosome biogenesis, and cell proliferation.
- To discuss DDX10's potential links to liquid-liquid phase separation (LLPS) and epigenetic regulation in cancer.
Main Methods:
- Literature review and synthesis of existing research on DDX10.
- Analysis of DDX10's structural and functional domains.
- Examination of DDX10's expression patterns and functional roles in solid tumors and hematologic malignancies.
Main Results:
- DDX10 contributes to fundamental cellular processes like pre-rRNA processing and ribosome biogenesis.
- Dysregulated DDX10 disrupts transcriptional homeostasis, promoting oncogenic transformation.
- Aberrant DDX10 expression is linked to tumor progression, therapy resistance, and poor prognosis.
- The NUP98::DDX10 fusion drives leukemogenesis in acute myeloid leukemia.
Conclusions:
- DDX10 is a key player in cancer biology, connecting aberrant RNA metabolism and altered molecular condensates.
- DDX10's tumor-associated expression and functions position it as a potential diagnostic biomarker.
- DDX10 represents a promising therapeutic target for various cancers, warranting further investigation.
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