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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Aortic Regurgitation I: Introduction01:15

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Integrated Transcriptomic Analysis Identifies Novel Candidate Genes Associated with Calcific Aortic Valve Disease.

Jing Chen1, Shichao Guo2, Junming Zhu2

  • 1Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 101118, China.

Genes
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Calcified aortic valve disease (CAVD) lacks pharmacological treatments. This study identifies BAMBI, HAND2, and MYOC as key genes downregulated in CAVD, offering potential therapeutic targets and biomarkers for this common valvular disorder.

Keywords:
BAMBIHAND2MYOCcalcified aortic valve disease (CAVD)machine learningosteogenesissingle-cell RNA sequencing

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genomics

Background:

  • Calcified aortic valve disease (CAVD) is a common condition in older adults, leading to aortic stenosis.
  • Current treatments for advanced CAVD involve valve replacement, but effective medications to slow disease progression are unavailable.
  • Identifying new biomarkers and therapeutic targets for CAVD is crucial.

Purpose of the Study:

  • To comprehensively analyze the transcriptional profile of CAVD using integrated transcriptomic data.
  • To identify novel candidate genes and pathways involved in CAVD pathogenesis.
  • To explore the potential of identified genes as biomarkers and therapeutic targets.

Main Methods:

  • Integrated analysis of multiple transcriptomic datasets.
  • Machine learning for feature gene identification.
  • Pathway enrichment, protein-protein interaction (PPI) network, and single-cell RNA sequencing (sc-RNA-Seq) analyses.
  • Validation using quantitative PCR and Western blot on human tissues.

Main Results:

  • Identified 119 CAVD-associated genes, mainly in ossification and extracellular matrix organization.
  • Discovered BAMBI, HAND2, and MYOC as significantly downregulated ossification genes in CAVD.
  • Observed decreased expression of these genes during VIC osteogenic progression and negative correlation with immune signatures.

Conclusions:

  • BAMBI, HAND2, and MYOC are novel candidate genes implicated in CAVD pathogenesis.
  • These genes represent potential biomarkers and therapeutic targets for CAVD.
  • Findings offer new insights into CAVD mechanisms and potential interventions.