Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Unique Bacteria01:18

Other Unique Bacteria

505
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
505
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

775
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
775
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

49.4K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
49.4K
Microbial Morphologies01:29

Microbial Morphologies

4.5K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
4.5K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

53.5K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
53.5K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

1.8K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbiota-miR-101 interactions in obesity-associated colorectal cancer: from barrier dysfunction to precision therapeutic strategies.

Frontiers in pharmacology·2026
Same author

A Rare Cause of Gastrointestinal Bleeding: Endoscopic Resection of a Large Brunner Gland Hamartoma.

Gastro hep advances·2026
Same author

Parabolic flight induces site specific microbiome changes in women.

Frontiers in microbiology·2026
Same author

The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.

Biomedicines·2026
Same author

Population Heterogeneity in Iron Biomarkers by Age, Sex, Menopausal Status, and Race in Healthy U.S. Adults: A Cross-Sectional Analysis from the All of Us Research Program.

Nutrients·2026
Same author

Feasibility of home-based, remotely delivered exercise training to improve physical function in older sepsis survivors: a pilot randomized controlled trial.

GeroScience·2026

Related Experiment Video

Updated: Feb 28, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.3K

Global Microbiome: Core and Unique Signatures Across Diverse Populations.

Sherri Huang1,2, Diptaraj S Chaudhari3, Rohit Shukla2,4

  • 1Kaiser Permanente San Leandro Medical Center, San Leandro, CA 94577, USA.

International Journal of Molecular Sciences
|February 27, 2026
PubMed
Summary

This meta-analysis reveals distinct gut microbiome signatures across global regions and age groups. Key bacterial phyla like Firmicutes and Bacteroidetes are prevalent, with age-related shifts and regional variations observed.

Keywords:
agingcoreenterotypeglobalmicrobiomeuniqueworld

More Related Videos

Exploring the Root Microbiome: Extracting Bacterial Community Data from the Soil, Rhizosphere, and Root Endosphere
09:55

Exploring the Root Microbiome: Extracting Bacterial Community Data from the Soil, Rhizosphere, and Root Endosphere

Published on: May 2, 2018

28.3K
Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing
08:05

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing

Published on: March 19, 2018

20.7K

Related Experiment Videos

Last Updated: Feb 28, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.3K
Exploring the Root Microbiome: Extracting Bacterial Community Data from the Soil, Rhizosphere, and Root Endosphere
09:55

Exploring the Root Microbiome: Extracting Bacterial Community Data from the Soil, Rhizosphere, and Root Endosphere

Published on: May 2, 2018

28.3K
Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing
08:05

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing

Published on: March 19, 2018

20.7K

Area of Science:

  • Microbiome research
  • Human gut microbiota
  • Comparative genomics

Background:

  • Previous gut microbiome studies lack standardized methods, hindering broad conclusions.
  • Understanding the gut microbiome's relationship with geography, age, and health is crucial.

Purpose of the Study:

  • To systematically analyze gut microbiome data across diverse geographic regions and age groups.
  • To identify global patterns and regional variations in gut microbial composition.
  • To explore age-related changes and health correlations within the gut microbiome.

Main Methods:

  • Meta-analysis of 16S rRNA sequencing data from 10,878 samples.
  • Inclusion of data from 27 countries across five continents.
  • Stratification of samples into three age groups: AG01 (0-17), AG02 (18-64), and AG03 (65+).

Main Results:

  • Firmicutes, Bacteroidetes, and Proteobacteria identified as core gut phyla globally.
  • Unique microbiome signatures found, with regional differences in bacterial families and genera (e.g., Bifidobacterium, Bacteroides).
  • Actinobacteria abundance decreased with age; Bacteroidetes increased from AG01 to AG02. Asthma-associated Enterobacteriaceae enriched in AG01, highest in North America.

Conclusions:

  • Gut microbiome composition varies significantly by geographic region and age.
  • Identified microbial patterns correlate with dietary habits, population health, and aging trends.
  • This study provides a comprehensive global overview of the human gut microbiome across diverse populations.