Related Experiment Video
Updated: Feb 28, 2026
06:26
Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
981
Genetic Predisposition to MASLD: Potential for Therapeutic Management
Fani Karapanagiotidi1, Chrysoula Boutari1, Emmanouil Sinakos1
14th Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece.
International Journal of Molecular Sciences
|February 27, 2026
Summary
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a growing global health issue. Genetic factors significantly influence MASLD, guiding precision medicine approaches for targeted treatments.
Area of Science:
- Hepatology and Genetic Epidemiology
Background:
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most prevalent liver condition globally, with rising incidence.
- Pathogenesis involves complex metabolic, environmental, and genetic factors.
Purpose of the Study:
- To review genetic variants influencing MASLD pathogenesis.
- To explore how these variants impact emerging pharmacotherapies and precision medicine.
Main Methods:
- Review of genome-wide association studies identifying key genetic variants (PNPLA3, TM6SF2, MBOAT7, GCKR, HSD17B13).
- Analysis of research on variant mechanisms in MASLD.
- Examination of clinical trials for precision medicine therapies.
Main Results:
- Specific genetic variants significantly contribute to MASLD development.
- These variants may affect patient response to novel drug therapies.
- Precision medicine offers individualized treatment strategies for MASLD.
Conclusions:
- Understanding genetic variants is crucial for MASLD pathogenesis.
- Pharmacogenomic approaches hold promise for targeted MASLD treatments.
- Clinical trials are evaluating precision medicine for MASLD management.
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