Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

3.5K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.5K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.5K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.5K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.3K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.3K
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

5.3K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
5.3K
The Extracellular Matrix01:42

The Extracellular Matrix

90.1K
Overview
90.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thioredoxin-interacting protein in fibrotic diseases: Mechanisms and therapeutic strategies.

The international journal of biochemistry & cell biology·2026
Same author

Current and Developing Therapeutics for Dry Eye Disease: Targeting Ion Channels.

Current issues in molecular biology·2026
Same author

Management of Dry Eye Disease Pre- and Post-Cataract Surgery: A Personalized Approach.

Journal of personalized medicine·2026
Same author

Cardiometabolic Risk Factors Impair Recompensation and Survival in Alcohol-associated Liver Disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Palmitic acid aggravates atopic dermatitis by regulating SGK1/NEDD4L-involved cutaneous neuroimmune inflammation through driving TRPV1 and MRGPRB2 S-palmitoylation.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same author

Ion-Defect Dual Management for Achieving Efficient Air-Processed Perovskite Solar Cells With Certified Efficiency 27.1.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
09:05

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

Published on: August 20, 2016

8.4K

Matrix Metalloproteinase 14 in Corneal Neovascularization.

Kaley Qin1, Nicholas W Setter1, Lily Yu1

  • 1Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.

International Journal of Molecular Sciences
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Matrix metalloproteinase-14 (MMP-14) is crucial in corneal neovascularization (CoNV) by remodeling the cornea and influencing blood vessel growth. Targeting MMP-14 offers new therapeutic strategies for CoNV, aiming to restore corneal clarity.

Keywords:
MMP-14TIMP-2VEGF signalingcorneal angiogenesiscorneal neovascularizationcorneal wound healingmatrix remodelingmetalloproteinase

More Related Videos

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
10:52

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

Published on: April 7, 2014

18.3K
Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
07:28

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

21.5K

Related Experiment Videos

Last Updated: Feb 28, 2026

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
09:05

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

Published on: August 20, 2016

8.4K
An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
10:52

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

Published on: April 7, 2014

18.3K
Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
07:28

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

21.5K

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Biochemistry

Background:

  • Corneal neovascularization (CoNV) impairs vision by disrupting the cornea's avascularity.
  • Matrix metalloproteinases (MMPs), particularly membrane-bound MMP-14, are key regulators of CoNV.
  • Current CoNV therapies show limited efficacy.

Purpose of the Study:

  • To elucidate the multifaceted role of MMP-14 in corneal neovascularization.
  • To explore MMP-14 as a therapeutic target for CoNV.

Main Methods:

  • Review of literature on MMP-14 function in corneal angiogenesis.
  • Analysis of MMP-14's pro-angiogenic and anti-angiogenic mechanisms.
  • Evaluation of existing and novel therapeutic strategies targeting MMP-14.

Main Results:

  • MMP-14 promotes CoNV via matrix degradation, growth factor signaling modulation, and endothelial cell migration.
  • MMP-14 also exhibits anti-angiogenic potential through fragment generation (e.g., neostatin-14).
  • MMP-14's involvement in corneal wound healing and lymphangiogenesis highlights its therapeutic relevance.

Conclusions:

  • MMP-14 is a critical mediator in CoNV, with both pro- and anti-angiogenic functions.
  • Targeting MMP-14 presents a promising avenue for novel CoNV therapies.
  • Further understanding of MMP-14 regulation is essential for effective therapeutic modulation of angiogenesis in the cornea.