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Updated: Feb 28, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Ru-Based NSAIDs as Potential Anticancer Therapeutics

Silvia Bordoni1, Magda Monari2, Carla Boga1

  • 1Department of Industrial Chemistry 'Toso Montanari', Alma Mater Studiorum, Università di Bologna, Via Piero Gobetti, 85, 40129 Bologna, Italy.

Molecules (Basel, Switzerland)
|February 27, 2026
PubMed
Summary

Novel ruthenium complexes were synthesized using non-steroidal anti-inflammatory drugs (NSAIDs) as ligands. One NSAID-ruthenium complex demonstrated significant antiproliferative effects against cancer cells, highlighting potential for new metallotherapeutics.

Keywords:
SCXRDcancermetallo-prodrugsruthenium

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