Ru-Based NSAIDs as Potential Anticancer Therapeutics
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Updated: Feb 28, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
Silvia Bordoni1, Magda Monari2, Carla Boga1
1Department of Industrial Chemistry 'Toso Montanari', Alma Mater Studiorum, Università di Bologna, Via Piero Gobetti, 85, 40129 Bologna, Italy.
Abstract:
The use of metal-based species bearing existing pharmaceuticals as ligands-often resulting in enhanced bioactivity-represents an attractive strategy for the development of novel therapeutic formulations. In this context, five well-known non-steroidal anti-inflammatory drugs (NSAIDs) were employed to substitute both PPh3 and hydride ligands in [Ru(H)2(CO)(PPh3)3] (1), thereby selectively affording neutral κ2-(O,O)-chelate complexes in satisfactory yields via molecular hydrogen release. Among the obtained species, two complexes coordinating diclofenac (4) and aspirin (5) were further investigated by single-crystal X-ray diffraction (SCXRD). Preliminary biological studies were conducted on the ruthenium-salicylic acid species 2 and ibuprofen 6. The former showed promising antiproliferative activity against HeLa cancer cells, consistent with the well-established role of NSAID-ruthenium(II) complexes as a platform for the development of novel anticancer metallotherapeutics.
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