Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SOPA and SIMPA: normalized single-sample integrated multiomics pathway analysis of tumor heterogeneity in solid cancers.

Briefings in bioinformatics·2026

Same author

Silent Messengers: The Role of Extracellular Vesicle-Associated miRNAs in the Non-Invasive Profiling of Hepatocellular Carcinoma.

Biomedicines·2026

Same author

Targeting the Warburg Effect in Anaplastic Thyroid Carcinoma: Metabolic Vulnerabilities and Therapeutic Opportunities.

International journal of molecular sciences·2026

Same author

Direct Maxillary Sinus Tissue Analysis for <i>TAS2R38</i> Polymorphisms: Establishing a Tissue-Based Translational Framework in Odontogenic Rhinosinusitis.

Journal of clinical medicine·2026

Same author

Comparative Effects of <i>Escherichia coli</i> vs. <i>Porphyromonas gingivalis</i> Lipopolysaccharides on Osteogenic Differentiation and the Expression of lncRNAs in Periodontal Ligament Stem Cells.

International journal of molecular sciences·2026

Same author

Evaluation of the Pharmacological Potential of <i>Psidium guajava</i> (Guava) and Its Anticancer Effect.

Pharmaceuticals (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Feb 28, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Molecular Signatures and Network Alterations Underlying GBM Progression and Recurrence.

Andrea Pop Crisan¹, Cristina Ciocan², Radu Pirlog^3,4

¹Department of Surgical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.

Medicina (Kaunas, Lithuania)

|February 27, 2026

Summary

This study reveals distinct molecular signatures in glioblastoma (GBM) progression, identifying gene expression patterns linked to tumor recurrence. These findings offer insights into GBM

Keywords:

GBM gene networks molecular pathways molecular signatures recurrent tumor

More Related Videos

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Related Experiment Videos

Last Updated: Feb 28, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Area of Science:

Neuro-oncology
Genomics
Molecular Biology

Background:

Glioblastoma (GBM) is an aggressive primary brain tumor with high recurrence and poor prognosis.
Understanding the molecular basis of GBM progression and recurrence is critical for improving patient outcomes.

Purpose of the Study:

Identify gene-expression signatures associated with primary and recurrent GBM.
Elucidate molecular networks and pathways driving GBM progression and recurrence.
Discover potential therapeutic targets for glioblastoma management.

Main Methods:

Analyzed The Cancer Genome Atlas (TCGA) gene expression data from tumor, recurrent, and normal brain tissues.
Identified differentially expressed genes and overlapping signatures between tumor states.
Utilized Ingenuity Pathway Analysis (IPA) for gene network and pathway analysis.

Main Results:

Discovered distinct molecular signatures differentiating tumor, recurrent, and normal brain samples.
Identified dysregulated genes related to cellular growth, proliferation, and migration.
Developed Tumor Scores (TS) and Recurrence Scores (RS) to classify samples into four distinct states: normal-like, proliferative, transitional, and recurrence-adapted.

Conclusions:

Glioblastoma exhibits progressive, recurrence-adapted molecular states.
Signaling networks and biological mechanisms underlying GBM recurrence are elucidated.
Findings may facilitate the identification of novel therapeutic strategies for glioblastoma.