Predictive Value of a Radiomics-Derived Risk Score for Local Progression in T3 Laryngeal Cancer: A 10-Year
Caglar Eker1, Muhammed Dagkiran1, Emin Demirel2
1Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, Cukurova University, Adana 01330, Turkey.
Journal of Clinical Medicine
|February 27, 2026
Summary
A new radiomics score from post-treatment CT scans can predict local progression in T3 laryngeal cancer patients after chemoradiotherapy. This tool helps identify patients needing closer monitoring for early treatment failure.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Predicting local progression in T3 laryngeal carcinoma (LC) after chemoradiotherapy is challenging with conventional methods.
- Early identification of treatment failure is crucial for patient outcomes.
Purpose of the Study:
- To develop a radiomics-derived risk score using post-treatment contrast-enhanced CT scans.
- To evaluate the prognostic value of this radiomics score for local progression-free survival (LPFS) in T3 LC patients.
Main Methods:
- Retrospective analysis of 67 T3 LC patients treated with chemoradiotherapy.
- Radiomics features extracted from post-treatment CT scans; a radiomics score (0-6) was constructed.
- Cox regression and Kaplan-Meier analyses were used to assess LPFS.
Main Results:
- The radiomics score independently predicted local progression (HR: 2.38, p < 0.001) with high discrimination (C-index: 0.855).
- Higher radiomics scores correlated with significantly shorter time to progression and poorer LPFS rates.
- 37.3% of patients experienced local progression during follow-up.
Conclusions:
- A post-treatment CT-derived radiomics score, combined with clinical data, effectively predicts local progression in T3 laryngeal cancer.
- This radiomics approach may enable personalized surveillance strategies by identifying high-risk patients.
- External validation is recommended to confirm these findings.
