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Antifungal Mechanism of 4-(4-Hydroxyphenyl)-2-butanone Against Fusarium solani

Yifan Chen1,2, Li Zhang1,2,3, Yan Chen1,2

  • 1School of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Zhengzhou 450001, China.

Microorganisms
|February 27, 2026
PubMed

Insights

4-(4-hydroxyphenyl)-2-butanone (RK), a metabolite from Bacillus amyloliquefaciens, effectively inhibits Fusarium solani growth. RK disrupts fungal cell membranes and mitochondria, offering new strategies for agricultural disease management.

Area of Science:

  • Agricultural Science
  • Mycology
  • Biochemistry

Background:

  • Fusarium solani is a significant plant pathogen impacting crop yields.
  • Its complex pathogenicity and resistance to control methods necessitate novel management strategies.

Purpose of the Study:

  • To identify and evaluate the antifungal activity of metabolites produced by Bacillus amyloliquefaciens against Fusarium solani.
  • To elucidate the mechanism of action of the identified antifungal compound.

Main Methods:

  • Liquid chromatography-time of flight mass spectrometry (LC-TOF-MS) for metabolite identification.
  • Antifungal assays to assess growth inhibition.
  • Physiological and biochemical assays to determine the mechanism of action.

Main Results:

  • 4-(4-hydroxyphenyl)-2-butanone (RK) was identified as a metabolite with potent antifungal activity against Fusarium solani.
  • RK significantly suppressed fungal growth.
  • RK was shown to disrupt the fungal cell membrane and mitochondrial function, leading to increased reactive oxygen species (ROS).

Conclusions:

  • RK exhibits significant antifungal properties against Fusarium solani.
  • The antifungal mechanism involves cell membrane and mitochondrial disruption.
  • RK presents a promising candidate for developing new agricultural disease management strategies.
Keywords:
4-(4-hydroxyphenyl)-2-butanoneFusarium solaniLC–TOF–MSantifungal mechanisms

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