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Related Experiment Video

Updated: Feb 28, 2026

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Genome-Wide Association Reveals Signalling-Linked Infection Tolerance in Hibernating Bats.

Markéta Harazim1,2, Lubomír Piálek1,3, Hana Bandouchova4

  • 1Institute of Vertebrate Biology, Czech Academy of Sciences, Květná 8, 60300 Brno, Czech Republic.

Pathogens (Basel, Switzerland)
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Genomic variations in bats influence their health during hibernation, affecting susceptibility to infections. Bats likely prioritize infection tolerance over resistance when hibernating due to these genetic factors.

Keywords:
Chiropteraadaptationgenome-wide association studyinfectionwhite-nose syndrome

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Area of Science:

  • Genomics
  • Immunology
  • Veterinary Science

Background:

  • Hibernation alters host-pathogen dynamics by suppressing metabolism and immune function.
  • This presents challenges for controlling infections in hibernating animals.

Purpose of the Study:

  • To investigate how genomic variation affects infection susceptibility and physiological traits in hibernating bats.
  • To identify specific genes and genetic variants associated with health traits during hibernation.

Main Methods:

  • Whole-genome sequencing was performed on five temperate bat species.
  • Infection screening, haematology, and blood biochemistry were conducted.
  • The phylogenetically informed treeWAS framework was used to associate single nucleotide variants (SNVs) with health variables.

Main Results:

  • Over 170,000 SNVs were identified, with 515 significantly linked to infections and physiological traits.
  • Associated SNVs mapped to 137 genes enriched in cytoskeletal dynamics, membrane trafficking, and intracellular signaling.
  • Canonical immune genes were underrepresented, suggesting regulatory loci are key.

Conclusions:

  • Bat genomic variation shapes physiological responses to infection under energy-limited hibernation.
  • Findings support the hypothesis that bats utilize infection tolerance rather than resistance during hibernation.
  • Regulatory and signaling pathways are crucial for maintaining hibernator health.