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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Polylactide Microparticles with Tunable Morphology for Biomedical Applications.

Vladislav Potseleev1,2, Sergey Uspenskii1,2, Ivan Kovtun1

  • 1Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsoyuznaya St., Moscow 117393, Russia.

Polymers
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Summary

Researchers developed a method to control polylactide (PLA) microparticle size and porosity for biomedical uses. This systematic approach optimizes PLA microparticle fabrication for drug delivery and tissue engineering applications.

Keywords:
biocompatible polymerbiodegradationcrystallinitypolylactideporous microstructure

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Polymer Chemistry

Background:

  • Precise control over polylactide (PLA) microparticle morphology is essential for biomedical applications.
  • Interdependent parameters like size, porosity, and surface topology present fabrication challenges.

Purpose of the Study:

  • To systematically investigate the fabrication of PLA microparticles with tunable architecture.
  • To understand the interplay of polymer molecular weight, concentration, and porogen type on microparticle morphology.

Main Methods:

  • Emulsion-solvent evaporation technique was employed.
  • Investigated polymer molecular weights (44-442 kDa), concentrations (0.5-20% w/v), and porogens (PEG, alkanes, lithium salts).

Main Results:

  • Achieved size control from 5 to 500 μm, influenced by viscosity and crystallization tendency.
  • Poly(L-lactide) yielded irregular particles; poly(D,L-lactide) formed spheres.
  • Alkanes allowed tailored pore networks; Li2CO3 in double emulsion enhanced macroporosity.

Conclusions:

  • Provides a foundational guideline for rational design of PLA microparticles.
  • Customized PLA microparticle properties can be achieved for targeted drug delivery and tissue engineering.