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Microbe-Derived Extracellular Vesicles as Carriers for Doxorubicin Delivery to Colorectal Cancer Cells
Sujin Lee1, Dagyeong Guk2,3, Youngdo Jeong2,4
1Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|February 27, 2026
Summary
Microbe-derived extracellular vesicles (MEVs) effectively deliver doxorubicin to colorectal cancer cells. These natural nanocarriers utilize specific cellular pathways for drug uptake, showing promise for cancer therapy.
Area of Science:
- Biotechnology
- Nanomedicine
- Cancer Research
Background:
- Microbe-derived extracellular vesicles (MEVs) offer a biocompatible drug delivery platform.
- Lactobacillus plantarum-derived EVs are explored for their therapeutic potential.
Purpose of the Study:
- To evaluate MEVs as nanocarriers for doxorubicin delivery to colorectal cancer cells.
- To elucidate the cellular uptake mechanisms of MEVs.
Main Methods:
- Doxorubicin was encapsulated into Lactobacillus plantarum-derived EVs.
- In vitro studies assessed drug delivery to colorectal cancer cells.
- Endocytosis inhibitors were employed to study cellular entry pathways.
Main Results:
- MEVs demonstrated structural stability under physiological conditions.
- Doxorubicin-loaded MEVs were internalized by cancer cells.
- Uptake involved clathrin/caveolae-dependent and dynamin-mediated endocytosis.
Conclusions:
- The microbe-cancer cell interaction facilitates drug uptake and intracellular delivery.
- MEVs show potential as nanocarriers for anticancer drugs.
- Mechanistic insights into intracellular trafficking pathways were gained.
