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Ginger and Its Purified Major Components Inhibit Clinically Relevant Uptake and Efflux Transporters In Vitro.

Tamás Varga1,2, Nóra Szilvásy2, Zsuzsanna Schelz3

  • 1Doctoral School of Biology, ELTE Eötvös Loránd University, H-1117 Budapest, Hungary.

Pharmaceutics
|February 27, 2026
PubMed
Summary

Ginger extract components, [6]-gingerol and [6]-shogaol, interact with numerous drug transporters. High-dose ginger may risk herb-drug interactions (HDIs) with medications by affecting transporters like OAT3.

Keywords:
ATP-binding cassette transportersZingiber officinalegingerolherb–drug interactionshogaolsolute carrier proteins

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