Inhaled Antibiotic and Biologic Formulations Targeting Pseudomonas aeruginosa
Prodip Kumar Baral1,2,3, Jack Dummer4, Daniel Pletzer2
1School of Pharmacy, Faculty of Health Professional Programmes, University of Otago, Dunedin 9054, New Zealand.
Pharmaceutics
|February 27, 2026
Summary
Inhaled antibiotics offer improved delivery for Pseudomonas aeruginosa lung infections. Novel formulations like nano-in-microparticles and biologics show promise for enhanced treatment in chronic lung diseases.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Drug Delivery Systems
Background:
- Lower respiratory tract infections caused by Pseudomonas aeruginosa are a global health concern.
- Chronic lung diseases like cystic fibrosis and bronchiectasis present challenges for effective antibiotic delivery.
- P. aeruginosa utilizes mechanisms such as biofilm formation and efflux pumps to resist antibiotics.
Purpose of the Study:
- To review current research and developments in inhaled antibiotic formulations for P. aeruginosa lung infections.
- To explore advancements in particle engineering for dry powder inhalers.
- To highlight emerging biologic therapies for inhalation.
Main Methods:
- Review of recent studies on micro, nano, and nano-in-microparticle engineering for inhaled antibiotics.
- Analysis of carrier-free microparticles, amino acid co-spray-dried systems, and nano-in-microsystems.
- Examination of emerging biologics including antibacterial proteins, peptides, vaccines, bacteriophages, and probiotics.
Main Results:
- Particle engineering strategies like nano-in-microparticles with lipid carriers demonstrate improved antibiofilm activity and controlled release.
- Amino acid incorporation enhances powder aerodynamics and moisture resistance in co-spray-dried systems.
- Inhaled antibiotics and biologics, particularly antimicrobial peptides and bacteriophages, show promising safety and efficacy profiles.
Conclusions:
- Direct drug delivery via inhaled formulations can increase antibiotic concentrations in the lung, potentially reducing treatment failure.
- Novel inhaled antibiotic formulations and biologic therapies offer promising strategies for combating P. aeruginosa lung infections.
- Further research into novel molecules, synergistic biologic combinations, and comprehensive animal lung safety studies is essential for future development.
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