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Biocompatible Dipeptide-Based Nanogels Incorporating Cinnamic Acid for Applications in Skin Disorder Therapy

Jülide Secerli1, Burcu Karayavuz2, Hakan Erdoğan3

  • 1Gülhane Faculty of Pharmacy, Department of Pharmaceutical Toxicology, University of Health Sciences Turkey, 06018 Ankara, Türkiye.

Pharmaceutics
|February 27, 2026
PubMed

Insights

Cinnamic acid (CA) shows promise for treating melanoma and promoting skin wound healing. When encapsulated in peptide nanogels, CA

Area of Science:

  • Dermatology
  • Nanotechnology
  • Pharmacology

Background:

  • Skin disorders like melanoma, aging, and chronic wounds severely affect quality of life.
  • Melanoma's high metastatic potential and resistance to chemotherapy pose significant clinical challenges.
  • There is a continuous need for advanced therapeutic strategies for skin aging and wound repair.

Purpose of the Study:

  • To enhance the stability and efficacy of cinnamic acid (CA) for dermatological applications.
  • To investigate the potential of CA-loaded Fmoc-FF dipeptide nanogels for treating melanoma and promoting wound healing.

Main Methods:

  • Cinnamic acid (CA) was incorporated into biocompatible Fmoc-FF dipeptide-based nanogels.
  • Antitumor effects were evaluated on human melanoma (SK-MEL-30) cells.
  • Wound healing activity was assessed using human keratinocyte (HaCaT) cells.

Main Results:

  • Cinnamic acid demonstrated significant antitumor activity against melanoma cells.
  • CA promoted wound healing in keratinocyte models.
  • Enhanced therapeutic effects were observed with CA delivered via Fmoc-FF nanogels.

Conclusions:

  • Cinnamic acid exhibits potent anticancer and wound-healing properties.
  • Fmoc-FF peptide nanogels serve as an effective delivery system for cinnamic acid.
  • CA-loaded peptide nanogels offer a promising multifunctional platform for treating diverse skin disorders.
Keywords:
Fmoc-FFmelanomaphytochemicalwound healing

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