Related Experiment Video
Updated: Feb 28, 2026
05:41
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
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Emerging Therapeutic Approaches for Modulating the Intestinal Microbiota.
Ilaria Cosimato1, Annalisa Brescia2, Gianluigi Franci1,3
1Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Pharmaceutics
|February 27, 2026
Summary
Emerging therapies like fecal microbiota transplantation (FMT) and phage therapy show promise for restoring gut microbial balance (eubiosis) and treating diseases linked to dysbiosis. Further research is needed for safety and standardization.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- The gut microbiota significantly impacts host metabolism, immunity, and disease.
- Microbial imbalance (dysbiosis) is linked to gastrointestinal and extraintestinal conditions.
- Restoring microbial balance (eubiosis) is crucial for human health.
Purpose of the Study:
- To review emerging therapeutic strategies for modulating the gut microbiota.
- To explore novel approaches for treating microbiota-associated diseases.
Main Methods:
- Narrative review of preclinical and clinical studies.
- Focus on fecal microbiota transplantation (FMT), bacterial consortium transplantation (BCT), phage therapy, and outer membrane vesicles (OMVs).
Main Results:
- Probiotics, prebiotics, and synbiotics show potential but are context-dependent.
- FMT is effective for recurrent Clostridioides difficile infections and being studied for other conditions.
- BCT, phage therapy, and OMVs are emerging strategies with early promising results.
Conclusions:
- Novel gut microbiota modulation strategies offer new avenues for precision medicine.
- These therapies could revolutionize disease prevention and treatment.
- Further research is essential to ensure safety, standardization, and clinical applicability.
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