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Updated: Feb 28, 2026
09:44
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
608
Ionic Liquid-Enabled Drug Delivery Systems: Benefits, Limitations, and Future Perspectives
1Department of Pharmaceutical Engineering, Hoseo University, Asan-si 31499, Chungnam, Republic of Korea.
Pharmaceutics
|February 27, 2026
Summary
Ionic liquids (ILs) enhance drug delivery systems (DDS) by improving solubility and stability. Rational design and standardized assessment are crucial for their clinical translation.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biotechnology
Background:
- Ionic liquids (ILs) offer tunable properties for drug delivery systems (DDS).
- They modulate biomolecular and interfacial interactions effectively.
- ILs can enhance API solubility, stability, and permeability.
Purpose of the Study:
- To review IL-enabled DDS strategies across various platforms.
- To emphasize formulation design principles for ILs in DDS.
- To assess limitations and future directions for ILs in drug delivery.
Main Methods:
- Review of nanocarrier-based systems, microtechnology-assisted devices, and biomacromolecule formulations.
- Analysis of ILs' role in API solubility, stability, and permeability.
- Examination of IL-membrane interactions and structure-activity relationships.
Main Results:
- ILs enhance drug formulation flexibility through API-IL complex formation.
- Mechanistic insights into IL-membrane interactions correlate with delivery performance and safety.
- Key limitations include toxicity, lack of standardized criteria, scalability, and regulatory issues.
Conclusions:
- ILs are valuable formulation-enabling materials for DDS.
- Rational design, standardized assessment, and early regulatory alignment are vital.
- Advancing IL-enabled DDS requires addressing current limitations for clinical translation.
Keywords:
biocompatibilitydrug delivery systemionic liquidsnanocarriersoral deliverytransdermal deliveryMore Related Videos
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