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Related Concept Videos

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Related Experiment Video

Updated: Feb 28, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

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Left Ventricular and Biventricular Multipoint Pacing With Dynamic Atrioventricular Delays: 6-Month Cardiac

Bernard Thibault1, Peter Waddingham2, Nima Badie3

  • 1From the Electrophysiology Service, Montreal Heart Institute, Université de Montréal, Montreal, Canada.

Journal of Cardiovascular Electrophysiology
|February 27, 2026
PubMed
Summary

Combining SyncAV CRT with MultiPoint Pacing (MPP) showed promising 6-month results for cardiac resynchronization therapy patients. Both biventricular and LV-only pacing improved echocardiographic and clinical outcomes.

Keywords:
atrioventricular delaycardiac resynchronization therapyechocardiographyleft ventricular pacingmultiPoint pacingreverse remodeling

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Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Trials

Background:

  • Cardiac resynchronization therapy (CRT) response varies with pacing location and timing.
  • Dynamic atrioventricular (AV) delays (SyncAV CRT) and multi-site left ventricular (LV) pacing (MPP) may improve CRT outcomes.
  • The combined effect of SyncAV and MPP in chronic settings is not well-studied.

Purpose of the Study:

  • To evaluate the 6-month echocardiographic and clinical response to SyncAV combined with biventricular MPP (MPP+SyncAV) or LV-only MPP (LVMPP+SyncAV).

Main Methods:

  • A multi-center study randomized CRT-indicated patients with LBBB and intact AV conduction.
  • Patients received either MPP+SyncAV (RV+LV1+LV2 pacing) or LVMPP+SyncAV (LV1+LV2 pacing).
  • SyncAV offsets were optimized to minimize QRS duration; echocardiographic and clinical metrics were assessed at baseline and 6 months.

Main Results:

  • 70 patients completed the study (MPP+SyncAV: n=36; LVMPP+SyncAV: n=34).
  • Both groups showed comparable improvements in LV end-systolic volume (ESV) and LV ejection fraction (EF) at 6 months.
  • Similar positive trends were observed for NYHA class, quality of life (QoL), and Packer scores across both groups.

Conclusions:

  • Combining SyncAV with MPP (biventricular or LV-only) demonstrated promising 6-month echocardiographic and clinical response rates in LBBB patients.
  • These findings suggest potential benefits of this combined pacing strategy for CRT.
  • Further research may explore long-term outcomes and broader patient populations.