Related Experiment Video

Updated: Feb 28, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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Asymmetric Reduction of Unactivated Alkenes

Nico D Fessner1, Sebastian Roth1, Richard Niese1

  • 1Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 27, 2026
PubMed
Summary

Asymmetric reduction of unactivated alkenes is challenging. Recent advances integrate chemical and biocatalytic strategies, including engineered enzymes and radical-based mechanisms, for more sustainable and selective synthesis.

Keywords:
alkene reductionbiocatalysisenzymatic reductionhydrogen atom transferunactivated alkenes

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