[Research progress of engineered microalgae in drug delivery].

Area of Science:

• Biomedical Engineering
• Materials Science
• Biotechnology

Background:

• Microalgae possess biocompatible, photosynthetically active biomass skeletons.
• Some microalgae species exhibit autonomous mobility, beneficial for targeted delivery.
• Microalgae are emerging as promising micro-nano materials for advanced applications.

Purpose of the Study:

• To review the progress of engineered microalgae in drug delivery.
• To discuss challenges hindering clinical translation of microalgae-based drug delivery.
• To provide insights for designing and applying microalgae platforms in biomedicine.

Main Methods:

• Review of current research on engineered microalgae for drug delivery.
• Analysis of microalgal properties relevant to drug delivery systems.
• Discussion of modification strategies for optimizing drug delivery and therapeutic outcomes.

Main Results:

• Engineered microalgae optimize drug delivery via programmable modifications.
• In-situ oxygen generation by microalgae provides auxiliary therapeutic effects.
• Microalgae-based platforms show potential for targeted and enhanced drug delivery.

Conclusions:

• Engineered microalgae represent a novel platform for advanced drug delivery.
• Addressing technical challenges is crucial for the clinical translation of these systems.
• Further research can optimize microalgae design for broader biomedical applications.