[Research progress of engineered microalgae in drug delivery]

The application of micro-nano materials in drug delivery has attracted increasing attention. As a photosynthetic group with excellent biocompatibility, microalgae have inherent advantages in this field. These organisms usually show easy-to-process biomass skeletons and remarkable photosynthetic activity, and some species have autonomous mobility. The engineered microalgal system optimizes drug delivery through programmable modifications and achieves auxiliary therapeutic effects through in-situ oxygen generation. This review summarizes the research progress in the use of engineered microalgae for drug delivery, discusses the technical challenges associated with their clinical translation, and provides insights for the design and biomedical application of microalgae-based platforms.