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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Vaccinations01:51

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Related Experiment Video

Updated: Feb 28, 2026

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
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Published on: December 5, 2025

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[Research progress in microneedle-mediated vaccination].

Zixin Wang1,2, Xiaoyang Li2, Yansong Zhang2

  • 1College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Microneedle vaccines offer an efficient alternative to traditional immunization, enhancing disease prevention and reducing mortality. This review explores microneedle technology for improved vaccine delivery and immunogenicity in infectious diseases and cancer immunotherapy.

Keywords:
clinical researchimmune mechanismmicroneedleprevention of diseasesvaccine

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Area of Science:

  • Biotechnology and Biomedical Engineering
  • Immunology and Vaccinology
  • Nanotechnology and Drug Delivery

Background:

  • Vaccination is a cornerstone of public health, crucial for preventing infectious diseases and reducing mortality.
  • Conventional immunization methods face challenges such as needle-phobia, cold-chain requirements, and administration complexities.
  • Microneedle technology presents a promising alternative for vaccine delivery, offering potential advantages over traditional approaches.

Purpose of the Study:

  • To review the fundamental principles of microneedle-mediated vaccination.
  • To discuss the preparation, types, and applications of microneedle-based vaccines.
  • To explore mechanisms of immune enhancement and strategies for improving immunogenicity using microneedles.

Main Methods:

  • Comprehensive literature review of microneedle technology in vaccination.
  • Analysis of different microneedle designs and fabrication techniques.
  • Examination of immunological responses elicited by microneedle-delivered vaccines.

Main Results:

  • Microneedles facilitate efficient and minimally invasive vaccine administration.
  • Various microneedle formulations demonstrate potential in preclinical models for infectious diseases and cancer immunotherapy.
  • Microneedle application enhances immune responses through improved antigen delivery and immune cell interaction.

Conclusions:

  • Microneedle vaccination is a viable strategy to overcome limitations of conventional methods, improving vaccine efficacy.
  • Further research into microneedle design and formulation can optimize immunogenicity and expand applications.
  • This technology holds significant promise for future vaccination strategies against a wide range of diseases.