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Using the misinformation exposure-trust framework for audience segmentation: Predicting COVID-19 vaccine hesitancy
Journal of Health Psychology
|February 27, 2026
Summary
Understanding COVID-19 vaccine misinformation exposure and trust helps segment audiences. This segmentation reveals distinct subgroups with varying vaccine hesitancy and health beliefs, informing targeted interventions.
Area of Science:
- Public Health
- Health Communication
- Social Psychology
Background:
- Misinformation regarding COVID-19 vaccines is prevalent.
- Understanding audience segmentation is crucial for effective health interventions.
- Vaccine hesitancy and health beliefs are influenced by information exposure and trust.
Purpose of the Study:
- To determine if exposure to and trust in COVID-19 vaccine misinformation can segment audiences.
- To explain variations in vaccine hesitancy and health beliefs based on misinformation exposure and trust.
- To identify distinct subgroups within a college student population based on their interaction with misinformation.
Main Methods:
- K-means clustering was employed to segment 819 U.S. college students.
- Participants were categorized based on high/low exposure and high/low trust in COVID-19 vaccine misinformation.
- Regression analyses were used to identify predictors of vaccine hesitancy.
Main Results:
- Four subgroups emerged: misinformation-shielded, misinformation-vulnerable, misinformation-resistant, and misinformation-accepting.
- Subgroups differed significantly in political ideology, vaccine hesitancy, and health beliefs.
- Perceived vaccine efficacy and safety were stable predictors of vaccine hesitancy.
Conclusions:
- The misinformation exposure-trust framework provides a theory-based approach for audience segmentation.
- Targeted health interventions can be developed based on these identified subgroups.
- Understanding misinformation dynamics is key to addressing vaccine hesitancy.
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