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Larger Substituents Enhance Stereospecificity in 1,1-Diazene Nitrogen Extrusion through Attenuation of Dynamic
Rong-Kai Wu1, Shuo-Qing Zhang1, Xin Hong1,2
1Center of Chemistry for Frontier Technologies, Department of Chemistry, State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, China.
Abstract:
Dynamic effects represent a crucial mechanism governing the stereoselectivity of nitrogen extrusion from 1,1-diazenes. Elucidating this dynamic behavior provides a mechanistic basis for enhancing nitrogen deletion selectivity. Using pyrrolidine ring contraction as a model reaction, we demonstrate how nitrogen extrusion dynamics control reaction selectivity. Quasiclassical dynamics trajectory simulations reveal that reaction selectivity is dynamically controlled: retention products predominate (60.1% of trajectories) while inversion products are significantly disfavored (3.7%). Mechanistic analysis reveals dynamic mismatching between ring-expansion motion and retention bonding in nitrogen extrusion. Incorporation of the sterically demanding 1-adamantyl substituent effectively promotes retention bonding, attenuates dynamic mismatching, and increases retention products to 79.0%. These results provide mechanistic insight into 1,1-diazene nitrogen extrusion and establish a foundation for rational design of more selective nitrogen deletion reactions.
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